Ginkgolide A
Ginkgolide A
CAS: 15291-75-5
Molecular Formula: C20H24O9
Ginkgolide A - Names and Identifiers
| Name | Ginkgolide A |
| Synonyms | lide A BN-52020 BN 52020 Ginkgolide A GINKGOLIDE A PRIMULIC ACID 1 1,7-DIDEOXYGINKGOLIDE C GINKGOLIDE A, GINKGO BILOBA L GINKGOLIDE A FROM GINKGO LEAVES |
| CAS | 15291-75-5 |
| EINECS | 604-873-4 |
| InChI | InChI=1/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17?,18?,19-,20?/m1/s1 |
| InChIKey | FPUXKXIZEIDQKW-VKMVSBOZSA-N |
Ginkgolide A - Physico-chemical Properties
| Molecular Formula | C20H24O9 |
| Molar Mass | 408.4 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Melting Point | 280°C (dec.) |
| Boling Point | 710.1±60.0 °C(Predicted) |
| Specific Rotation(α) | D24 -53.4° (c = 1 in ethanol) |
| Flash Point | 256.5°C |
| Solubility | Dissolved in solvents such as ethyl acetate, methanol, ethanol, dimethyl sulfoxide, etc. |
| Vapor Presure | 2.69E-23mmHg at 25°C |
| Appearance | White needle crystal (methanol) |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['219nm(EtOH)(lit.)'] |
| pKa | 11.45±0.70(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.631 |
| MDL | MFCD00133365 |
| Physical and Chemical Properties | White crystals, soluble in methanol, acetone, insoluble in water, from Ginkgo biloba. |
| In vitro study | Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A (BN-52020) failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons. |
| In vivo study | Ginkgolide A significantly shortened the sleeping time in anesthetized mice. |
Ginkgolide A - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | KC9943000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29322090 |
Ginkgolide A - Reference
| Reference Show more | 1. Feng Ru, Li Zehong, Yuan Honghui, et al. Effects of Different Stress Treatments on Terpene Lactone Content in Ginkgo Biloba Leaves [J]. Journal of Wuhan Institute of Technology 2017 036(001):34-38 53. 2. Zhang Xianglun, Wu Dawei, Lu Peng, et al. Effects of Ordinary and Ultrafine Grinding on Release of Flavonoids and Terpene Lactones from Ginkgo Biloba Leaves [J]. Grain and Feed Industry, 2014, 12(006):45-47. 3. Liu Zhishuang, Zheng Yinfen, Sun Hongna, et al. Effect of Ginkgo biloba extract on anticoagulant activity of 4 oral anticoagulants. 4. Zhang, Wen, et al. "Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling." Acta Pharmacologica Sinica 39.8 (2018): 1259-1272.https://doi.org/10.1038/aps.2017.149 5. Zhang, Xianglun, et al. "Effect of Ginkgo biloba Leaf Powder on Growth Performance, meat Quality and Antioxidant Activity of Muscle in Growing-Finishing Pigs." Pakistan Journal of Zoology 48.5 (2016). 6. Zhang, Xianglun, et al. "Effect of Ginkgo biloba Leaf Powder on Growth Performance, meat Quality and Antioxidant Activity of Muscle in Growing-Finishing Pigs." Pakistan Journal of Zoology 48.5 (2016). 7. [IF = 5.064] Zhang Wen et al. "Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling." Acta Pharmacol Sin.2018 Mar;39(8): 1259-1272 8. [IF = 3.935] Xingliang Niu et al. "Hydrogen/deuterium exchange, a unique and effective method for MS fragmentation behavior elucidation of ginkgolides and its application to systematic research in Ginkgo biloba." J Pharmaceut Biomed.2017 Feb;134:181 9. [IF = 9.297] Minmin Zou et al. "Removal of ginkgotoxin from the Ginkgo biloba seeds powder by adopting membrane separation technology." J Clean Prod. 2021 Jan;280:124452 10. [IF = 5.645] Ying Guo et al. "Spatial prediction and delineation of Ginkgo biloba production areas under current and future climatic conditions." Ind Crop Prod. 2021 Aug;166:113444 11. [IF = 4.36] Xiao-Xue Fan et al. "Diterpene Ginkgolides Meglumine Injection inhibits apoptosis induced by optic nerve crush injury via modulating MAPKs signaling pathways in retinal ganglion cells." J Ethnopharmacol. 2021 Oct;279:114371 12. [IF = 3.638] Wen Zhang et al. "Efficient removal of ginkgotoxin from Ginkgo biloba seed powder by combining endogenous enzymatic hydrolysis with resin adsorption." J Sci Food Ag.2021 Mar;101(4):1589-1597 13. [IF = 5.645] Qihui Dong et al. "Solubilization of phytocomplex using natural deep eutectic solvents: A case study of Ginkgo biloba leaves extract." Ind Crop Prod. 2022 Mar;177:114455 14. [IF = 3.935] Yongyi Li et al. "Integrated molecular networking strategy enhance the accuracy and visualization of components identification: A case study of Ginkgo biloba leaf extract." J Pharmaceut Biomed. 2022 Feb;209:114523 |
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